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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Ouaked, N; Mantel, PY; Bassin, C; Burgler, S; Siegmund, K; Akdis, CA; Schmidt-Weber, CB 
Title:
Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1. 
Abstract:
Impaired functional activity of T regulatory cells has been reported in allergic patients and results in an increased susceptibility to autoimmune diseases. The master regulator of T regulatory cell differentiation, the transcription factor FOXP3, is required for both their development and function. Despite its key role, relatively little is known about the molecular mechanisms regulating foxp3 gene expression. In the present study, the effect of Th1 cytokines on human T regulatory cell differen...    »
 
Journal title abbreviation:
J Immunol 
Year:
2009 
Journal volume:
182 
Journal issue:
Pages contribution:
1041-9 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)