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Titel:

Contrast-enhanced whole-heart MR coronary angiography at 3.0 T using the intravascular contrast agent gadofosveset.

Dokumenttyp:
journal article
Autor(en):
Prompona, M; Cyran, C; Nikolaou, K; Bauner, K; Reiser, M; Huber, A
Abstract:
OBJECTIVES: The purpose of this study was to compare contrast-enhanced (CE) whole-heart coronary magnetic resonance angiography (MRA) at 3.0 T using gadofosveset to noncontrast-enhanced steady-state free precession (SSFP) coronary MRA at 1.5 T. MATERIALS AND METHODS: A prospective randomized study was conducted among 20 healthy male volunteers. The same group of subjects underwent CE whole heart MRA at 3.0 T employing a 3D FLASH sequence with IR prepulse after gadofosveset injection as well as noncontrast-enhanced coronary MRA at 1.5 T using a 3D SSFP sequence with T2-preparation. Both techniques were performed using prospective ECG-triggering and adaptive respiratory gating. Acquisition time, signal-to-noise ratio of coronary blood, contrast-to-noise ratio (CNR) between coronaries and adjacent myocardium or epicardial fat, and image quality were evaluated in each case. RESULTS: A significant increase of the overall CNR between coronary blood and adjacent myocardium was measured on images acquired at 3 T in comparison to 1.5 T. The mean values were 38.9 +/- 19.6 and 26.3 +/- 15.4, respectively (P[r]< 0.005). There was no significant difference in CNR between coronary blood and epicardial fat. The mean image quality for the proximal and mid coronary segments was not statistically different between 1.5 T and 3.0 T (P> 0.05), however, the distal coronary segments were rated significantly higher for the CE MRA at 3.0 T (P = 0.02). The average acquisition time (15.29 +/- 5.73 minutes at 1.5 T vs. 17.29 +/- 5.18 minutes at 3 T) and overall image quality (2.15 +/- 0.49 at 1.5 T vs. 2.35 +/- 0.39 at 3 T) were similar for both methods. CONCLUSIONS: CE whole-heart coronary MRA at 3.0 T demonstrated higher overall CNR between coronary blood and myocardium and an improved image quality of the distal coronary segments compared with noncontrast-enhanced SSFP coronary MRA at 1.5 T.
Zeitschriftentitel:
Invest Radiol
Jahr:
2009
Band / Volume:
44
Heft / Issue:
7
Seitenangaben Beitrag:
369-74
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19554666
Print-ISSN:
0020-9996
TUM Einrichtung:
Röntgendiagnostik
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