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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review 
Author(s):
Vilardaga, JP; Bünemann, M; Feinstein, TN; Lambert, N; Nikolaev, VO; Engelhardt, S; Lohse, MJ; Hoffmann, C 
Title:
GPCR and G proteins: drug efficacy and activation in live cells. 
Abstract:
Many biochemical pathways are driven by G protein-coupled receptors, cell surface proteins that convert the binding of extracellular chemical, sensory, and mechanical stimuli into cellular signals. Their interaction with various ligands triggers receptor activation that typically couples to and activates heterotrimeric G proteins, which in turn control the propagation of secondary messenger molecules (e.g. cAMP) involved in critically important physiological processes (e.g. heart beat). Successf...    »
 
Journal title abbreviation:
Mol Endocrinol 
Year:
2009 
Journal volume:
23 
Journal issue:
Pages contribution:
590-9 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0888-8809 
TUM Institution:
Institut für Pharmakologie und Toxikologie 
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