/=0.1 mug/g creatinine. However, isotopic results in blood detected DU in only half of the subcohort who had isotopic signatures for DU detectable in urine. After stratifying the cohort based on urine U concentration, the high-U group showed a trend toward higher concentrations of urine beta(2) microglobulin compared to the low-U group (81.7 v. 69.0 mug/g creat.; p = .11 respectively) and retinol binding protein (48.1 vs. 31.0 mug/g creat.; p = .07 respectively). Bone metabolism parameters showed only subtle differences between groups. Sixteen years after first exposure, this cohort continues to excrete elevated concentrations of urine U as a function of DU shrapnel burden. Although subtle trends emerge in renal proximal tubular function and bone formation, the cohort exhibits few clinically significant U-related health effects."/>
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Document type:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S. 
Author(s):
McDiarmid, MA; Engelhardt, SM; Dorsey, CD; Oliver, M; Gucer, P; Wilson, PD; Kane, R; Cernich, A; Kaup, B; Anderson, L; Hoover, D; Brown, L; Albertini, R; Gudi, R; Squibb, KS 
Title:
Surveillance results of depleted uranium-exposed Gulf War I veterans: sixteen years of follow-up. 
Abstract:
As part of a longitudinal surveillance program, 35 members of a larger cohort of 77 Gulf War I veterans who were victims of depleted uranium (DU) "friendly fire" during combat underwent a 3-day clinical assessment at the Baltimore Veterans Administration Medical Center (VAMC). The assessment included a detailed medical history, exposure history, physical examination, and laboratory studies. Spot and 24-h urine collections were obtained for renal function parameters and for urine uranium (U) meas...    »
 
Journal title abbreviation:
J Toxicol Environ Health A 
Year:
2009 
Journal volume:
72 
Journal issue:
Pages contribution:
14-29 
Language:
eng 
Print-ISSN:
1528-7394 
TUM Institution:
Institut für Pharmakologie und Toxikologie 
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