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Title:

Phosphodiesterases in the central nervous system.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Kleppisch, T
Abstract:
Phosphodiesterases (PDEs) represent important cornerstones of cGMP signaling in various tissues. Since the discovery of PDE activity in 1962, it has become clear that the functional characteristics of PDEs and their role in cyclic nucleotide signaling are fairly complex. On the one hand, members of the PDE family responsible for the hydrolysis of cGMP affect cellular responses by shaping cGMP signals derived from the activation of soluble cytosolic and/or membrane bound particulate guanylyl cycl...     »
Journal title abbreviation:
Handb Exp Pharmacol
Year:
2009
Journal issue:
191
Pages contribution:
71-92
Language:
eng
Fulltext / DOI:
doi:10.1007/978-3-540-68964-5_5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19089326
Print-ISSN:
0171-2004
TUM Institution:
Institut für Pharmakologie und Toxikologie
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