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Title:

Graft preconditioning with low-dose tacrolimus (FK506) and nitric oxide inhibitor aminoguanidine (AGH) reduces ischemia/reperfusion injury after liver transplantation in the rat.

Document type:
Journal Article; Article
Author(s):
Hüser, N; Doll, D; Altomonte, J; Werner, M; Kriner, M; Preissel, A; Thorban, S; Matevossian, E
Abstract:
Ischemia/reperfusion (I/R) injury is a main cause of primary dysfunction or non-function after liver transplantation (LTx). Recent evidence indicates that an increase in nitric oxide (NO) production after LTx is associated with I/R injury. The aim of this study was to demonstrate that low-dose FK506 in combination with aminoguanidine (AGH), which leads to a reduction of NO levels, has a protective effect by reducing I/R associated injury after LTx. Fortyone DA-(RT1av1) rats served as donors and...     »
Journal title abbreviation:
Arch Pharm Res
Year:
2009
Journal volume:
32
Journal issue:
2
Pages contribution:
215-20
Language:
eng
Fulltext / DOI:
doi:10.1007/s12272-009-1138-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19280151
Print-ISSN:
0253-6269
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Statistik und Epidemiologie
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