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Title:

A common variant on chromosome 11q13 is associated with atopic dermatitis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Esparza-Gordillo, J; Weidinger, S; Folster-Holst, R; Bauerfeind, A; Rüschendorf, F; Patone, G; Rohde, K; Marenholz, I; Schulz, F; Kerscher, T; Hübner, N; Wahn, U; Schreiber, S; Franke, A; Vogler, R; Heath, S; Baurecht, H; Novak, N; Rodriguez, E; Illig, T; Lee-Kirsch, MA; Ciechanowicz, A; Kurek, M; Piskackova, T; Macek, M; Lee, YA; Ruether, A
Abstract:
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined)...     »
Journal title abbreviation:
Nat Genet
Year:
2009
Journal volume:
41
Journal issue:
5
Pages contribution:
596-601
Language:
eng
Fulltext / DOI:
doi:10.1038/ng.347
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19349984
Print-ISSN:
1061-4036
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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