Benutzer: Gast  Login
Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't 
Autor(en):
Aly, S; Mages, J; Reiling, N; Kalinke, U; Decker, T; Lang, R; Ehlers, S 
Titel:
Mycobacteria-induced granuloma necrosis depends on IRF-1. 
Abstract:
In a mouse model of mycobacteria-induced immunopathology, wild-type C57BL/6 (WT), IL-18-knockout (KO) and IFN-alphabeta receptor-KO mice developed circumscript, centrally necrotizing granulomatous lesions in response to aerosol infection with M. avium, whereas mice deficient in the IFN-gamma receptor, STAT-1 or IRF-1 did not exhibit granuloma necrosis. Comparative, microarray-based gene expression analysis in the lungs of infected WT and IRF-1-KO mice identified a set of genes whose differential...    »
 
Zeitschriftentitel:
J Cell Mol Med 
Jahr:
2009 
Band / Volume:
13 
Heft / Issue:
8B 
Seitenangaben Beitrag:
2069-82 
Sprache:
eng 
Print-ISSN:
1582-1838 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene 
Versionen