User: Guest  Login
Document type:
Journal Article
Author(s):
Hoboth, C; Hoffmann, R; Eichner, A; Henke, C; Schmoldt, S; Imhof, A; Heesemann, J; Hogardt, M
Title:
Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis.
Abstract:
BACKGROUND: In patients with cystic fibrosis (CF), the emergence of hypermutable Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently adapted to the inflamed lungs of these patients. OBJECTIVE: To provide a detailed survey of adaptive changes in the physiology of P. aeruginosa during chronic lung infection in patients with CF. METHODS: We performed a comparative proteome and transcriptome analysis of sequential, isogenic isolates recovered over a period of 3...    »
Journal title abbreviation:
J Infect Dis
Year:
2009
Journal volume:
200
Journal issue:
1
Pages contribution:
118-30
Language:
eng
Fulltext / DOI:
doi:10.1086/599360
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19459782
Print-ISSN:
0022-1899
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX