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Title:

Mycobacteria-induced granuloma necrosis depends on IRF-1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Aly, S; Mages, J; Reiling, N; Kalinke, U; Decker, T; Lang, R; Ehlers, S
Abstract:
In a mouse model of mycobacteria-induced immunopathology, wild-type C57BL/6 (WT), IL-18-knockout (KO) and IFN-alphabeta receptor-KO mice developed circumscript, centrally necrotizing granulomatous lesions in response to aerosol infection with M. avium, whereas mice deficient in the IFN-gamma receptor, STAT-1 or IRF-1 did not exhibit granuloma necrosis. Comparative, microarray-based gene expression analysis in the lungs of infected WT and IRF-1-KO mice identified a set of genes whose differential...     »
Journal title abbreviation:
J Cell Mol Med
Year:
2009
Journal volume:
13
Journal issue:
8B
Pages contribution:
2069-82
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1582-4934.2008.00470.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18705699
Print-ISSN:
1582-1838
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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