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Title:

Optical biosensor-based characterization of anti-double-stranded DNA monoclonal antibodies as possible new standards for laboratory tests.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Buhl, A; Page, S; Heegaard, NH; von Landenberg, P; Luppa, PB
Abstract:
The serum determination of circulating anti-double-stranded (ds)DNA autoantibodies is a routine measure for the laboratory diagnosis of systemic lupus erythematosus. Since available assays differ substantially and no feasible calibrator is available, the aim of this study was to evaluate a recently introduced surface plasmon resonance (SPR) biosensor chip for binding studies between dsDNA and anti-dsDNA autoantibodies and to demonstrate its usefulness for the characterization of new monoclonal a...     »
Journal title abbreviation:
Biosens Bioelectron
Year:
2009
Journal volume:
25
Journal issue:
1
Pages contribution:
198-203
Language:
eng
Fulltext / DOI:
doi:10.1016/j.bios.2009.06.037
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19632822
Print-ISSN:
0956-5663
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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