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Titel:

Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Fritsche, LG; Freitag-Wolf, S; Bettecken, T; Meitinger, T; Keilhauer, CN; Krawczak, M; Weber, BH
Abstract:
Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing) and E4 (protective). The biological correlate of this association, however, is still unclear. In this study, we have defined an extended haplotype block encompassing the entire APOE gene locus, includ...     »
Zeitschriftentitel:
Hum Mutat
Jahr:
2009
Band / Volume:
30
Heft / Issue:
7
Seitenangaben Beitrag:
1048-53
Sprache:
eng
Volltext / DOI:
doi:10.1002/humu.20957
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19384966
Print-ISSN:
1059-7794
TUM Einrichtung:
Institut für Humangenetik
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