Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality

Altmaier, E.; Emeny, R. T.; Krumsiek, J.; Lacruz, M. E.; Lukaschek, K.; Häfner, S.; Kastenmüller, G.; Römisch-Margl, W.; Prehn, C.; Mohney, R. P.; Evans, A. M.; Milburn, M. V.; Illig, T.; Adamski, J.; Theis, F. J.; Suhre, K.; Ladwig, K. H.

Benutzer: Gast

Lehrstuhl für Mathematische Modelle biologische Systeme (Prof. Theis)

Zurück
Zurück zum Anfang der Trefferliste
Dauerhafter Link zum angezeigten Objekt

Titel:: Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality
Autor(en):: Altmaier, E.; Emeny, R. T.; Krumsiek, J.; Lacruz, M. E.; Lukaschek, K.; Häfner, S.; Kastenmüller, G.; Römisch-Margl, W.; Prehn, C.; Mohney, R. P.; Evans, A. M.; Milburn, M. V.; Illig, T.; Adamski, J.; Theis, F. J.; Suhre, K.; Ladwig, K. H.
Abstract:: Background Individuals with negative affectivity who are inhibited in social situations are characterized as distressed, or Type D, and have an increased risk of cardiovascular disease (CVD). The underlying biomechanisms that link this psychological affect to a pathological state are not well understood. This study applied a metabolomic approach to explore biochemical pathways that may contribute to the Type D personality. Methods Type D personality was determined by the Type D Scale-14. Small molecule biochemicals were measured using two complementary mass-spectrometry based metabolomics platforms. Metabolic profiles of Type D and non-Type D participants within a population-based study in Southern Germany were compared in cross-sectional regression analyses. The PHQ-9 and GAD-7 instruments were also used to assess symptoms of depression and anxiety, respectively, within this metabolomic study. Results 668 metabolites were identified in the serum of 1502 participants (age 32– 77); 386 of these individuals were classified as Type D. While demographic and biomedical characteristics were equally distributed between the groups, a higher level of depression and anxiety was observed in Type D individuals. Significantly lower levels of the tryptophan metabolite kynurenine were associated with Type D (p-value corrected for multiple testing = 0.042), while no significant associations could be found for depression and anxiety. A Gaussian graphical model analysis enabled the identification of four potentially interesting metabolite networks that are enriched in metabolites (androsterone sulfate, tyrosine, indoxyl sulfate or caffeine) that associate nominally with Type D personality. Conclusions This study identified novel biochemical pathways associated with Type D personality and demonstrates that the application of metabolomic approaches in population studies can reveal mechanisms that may contribute to psychological health and disease.
Stichworte:: Type D personality Negative affectivity Social inhibition Metabolomics Population study Kynurenine
Zeitschriftentitel:: Psychoneuroendocrinology
Jahr:: 2013
Band / Volume:: 38
Heft / Issue:: 8
Seitenangaben Beitrag:: 1299-1309
BibTeX

Vorkommen:

mediaTUM Gesamtbestand Hochschulbibliographie 2013 Fakultäten Mathematik Lehrstuhl für Mathematische Modelle biologische Systeme (Prof. Theis)

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Computation, Information and Technology Departments Mathematics Lehrstuhl für Mathematische Modellierung biologischer Systeme (Prof. Theis)