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Title:

Bayesian model selection validates a biokinetic model for zirconium processing in humans

Author(s):
Schmidl, D.; Hug, S.; Li, W. B.; Greiter, M. B.; Theis, F. J.
Abstract:
ABSTRACT: BACKGROUND: In radiation protection, biokinetic models for zirconium processing are of crucial importance in dose estimation and further risk analysis for humans exposed to this radioactive substance. They provide limiting values of detrimental effects and build the basis for applications in internal dosimetry, the prediction for radioactive zirconium retention in various organs as well as retrospective dosimetry. Multi-compartmental models are the tool of choice for simulating the pro...     »
Keywords:
Bayesian inference Model selection MCMC sampling Compartmental model Internal dosimetry Systems biology
Journal title:
BMC Syst. Biol.
Year:
2012
Journal volume:
6
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