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Titel:

Stability and multiattractor dynamics of a toggle switch based on a two-stage model of stochastic gene expression

Autor(en):
Strasser, M.; Theis, F. J.; Marr, C.
Abstract:
A toggle switch consists of two genes that mutually repress each other. This regulatory motif is active during cell differentiation and is thought to act as a memory device, being able to choose and maintain cell fate decisions. Commonly, this switch has been modeled in a deterministic framework where transcription and translation are lumped together. In this description, bistability occurs for transcription factor cooperativity, whereas autoactivation leads to a tristable system with an additio...     »
Zeitschriftentitel:
Biophys. J.
Jahr:
2012
Band / Volume:
102
Heft / Issue:
1
Seitenangaben Beitrag:
19-29
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