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Title:

Decreased FOXP3 protein expression in patients with asthma.

Document type:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Provoost, S; Maes, T; van Durme, YM; Gevaert, P; Bachert, C; Schmidt-Weber, CB; Brusselle, GG; Joos, GF; Tournoy, KG
Abstract:
T-regulatory cells (T(reg)) are important in balancing immune responses and maintaining peripheral tolerance. Current evidence suggests that asthma is characterized by a relative deficiency in T(reg), allowing T helper 2 cells to expand. In this study, we aimed to evaluate circulating T(reg), defined by the protein FOXP3, in both control subjects and patients with stable asthma.Peripheral blood mononuclear cells (PBMC) of control (n = 14) and asthmatic patients (n = 29) were labeled for CD4, CD2...     »
Journal title abbreviation:
Allergy
Year:
2009
Journal volume:
64
Journal issue:
10
Pages contribution:
1539-46
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1398-9995.2009.02056.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19392991
Print-ISSN:
0105-4538
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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