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Titel:

The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes.

Dokumenttyp:
Journal Article; Article
Autor(en):
Laumen, H; Skurk, T; Hauner, H
Abstract:
Human preadipocytes and adipocytes are known to produce the proatherogenic factor PAI-1 and proinflammatory cytokines, and obesity was found to be state of increased adipose production of these factors. In the present study, we investigated the effect of rosuvastatin on the regulation of PAI-1 gene expression in human adipocytes. Human preadipocytes, adipocytes in primary culture and the SGBS cell line were used as cell models. Cells were transfected using various constructs and promoter activit...     »
Zeitschriftentitel:
Atherosclerosis
Jahr:
2008
Band / Volume:
196
Heft / Issue:
2
Seitenangaben Beitrag:
565-73
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.atherosclerosis.2007.06.005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17692320
Print-ISSN:
0021-9150
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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