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Titel:

Seeking Innovative Affinity Approaches: A Performance Comparison between Magnetic Nanoparticle Agglomerates and Chromatography Resins for Antibody Recovery

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Padwal P, Finger C, Fraga-García P, Kaveh-Baghbaderani Y, Schwaminger S, Berensmeier S:
Abstract:
Monoclonal antibodies are key molecules in medicine and pharmaceuticals. A potentially crucial drawback for faster advances in research here is their high price due to the extremely expensive antibody purification process, particularly the affinity capture step. Affinity chromatography materials have to demonstrate the high binding capacity and recovery efficiency as well as superior chemical and mechanical stability. Low-cost materials and robust, faster processes would reduce costs and...     »
Stichworte:
immunoglobulin purification, affinity chromatography, protein A, protein G, protein immobilization, ligand density, magnetic separation, iron oxide nanoparticles, nanoparticle agglomeration
Zeitschriftentitel:
ACS Applied Materials & Interfaces
Jahr:
2020
Jahr / Monat:
2020-08
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1021/acsami.0c05007
WWW:
https://pubs.acs.org/doi/10.1021/acsami.0c05007
TUM Einrichtung:
Professur für Selektive Trenntechnik
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