Many cancer cells acquire mechanisms to escape the host immune system for example by presenting immune checkpoint molecules such as PD-L1 on the cell surface. The transcription factor MYC plays an essential role in the pathogenesis of aggressive B-cell non hodgkin lymphomas (NHL). We demonstrate that MYC(+) B-cell NHL show a reduced expression of immune checkpoint molecules. Furthermore, we provide evidence that MYC can negatively regulate PD-L1 expression in a MYC-inducible human lymphoma cell line.     «

Many cancer cells acquire mechanisms to escape the host immune system for example by presenting immune checkpoint molecules such as PD-L1 on the cell surface. The transcription factor MYC plays an essential role in the pathogenesis of aggressive B-cell non hodgkin lymphomas (NHL). We demonstrate that MYC(+) B-cell NHL show a reduced expression of immune checkpoint molecules. Furthermore, we provide evidence that MYC can negatively regulate PD-L1 expression in a MYC-inducible human lymphoma cell...     »