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Titel:

Wisdom of crowds for robust gene network inference

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Drton, Mathias (as part of the ‘DREAM5 Consortium’)
Abstract:
Reconstructing gene regulatory networks from high-throughput data is a long-standing challenge. Through the Dialogue on Reverse Engineering Assessment and Methods (DREAM) project, we performed a comprehensive blind assessment of over 30 network inference methods on Escherichia coli, Staphylococcus aureus, Saccharomyces cerevisiae and in silico microarray data. We characterize the performance, data requirements and inherent biases of different inference approaches, and we provide guidelines for a...     »
Dewey Dezimalklassifikation:
510 Mathematik
Zeitschriftentitel:
Nature Methods
Jahr:
2012
Band / Volume:
9
Jahr / Monat:
2012-07
Quartal:
3. Quartal
Monat:
Jul
Seitenangaben Beitrag:
796-804
Sprache:
en
Volltext / DOI:
doi:https://doi.org/10.1038/nmeth.2016
WWW:
Nature Methods
Verlag / Institution:
Springer Science and Business Media LLC
E-ISSN:
1548-70911548-7105
Publikationsdatum:
15.07.2012
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