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Titel:

Charged glycan residues critically contribute to the adsorption and lubricity of mucins

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Marczynski, Matthias; Balzer, Bizan N.; Jiang, Kun; Lutz, Theresa M.; Crouzier, Thomas; Lieleg, Oliver
Abstract:
In the human body, mucin glycoproteins efficiently reduce friction between tissues and thereby protect the mucosa from mechanical damage. Mucin lubricity is closely related to their molecular structure: it has been demonstrated previously that the hydrophobic termini of mucins critically contribute to their lubricity. If and how intrinsic sources of negative charge in mucins, e.g., sulfated glycans and sialic acid residues, are relevant for the tribological behavior of mucin solutions has, howev...     »
Stichworte:
Adsorption, AFM, DNA, Lubricity, Mucin, QCM-D, Sialic acid, Sulfate, Tribology
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Colloids and Surfaces B: Biointerfaces
Jahr:
2020
Band / Volume:
187
Seitenangaben Beitrag:
110614
Nachgewiesen in:
Scopus
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1016/j.colsurfb.2019.110614
WWW:
https://www.sciencedirect.com/science/article/abs/pii/S0927776519307581
Verlag / Institution:
Elsevier BV
E-ISSN:
0927-7765
Publikationsdatum:
01.03.2020
TUM Einrichtung:
Fachgebiet für Biomechanik
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