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Title:

DNA Strands Trigger the Intracellular Release of Drugs from Mucin-Based Nanocarriers

Document type:
Zeitschriftenaufsatz
Author(s):
Kimna, Ceren; Lutz, Theresa Monika; Yan, Hongji; Song, Jian; Crouzier, Thomas; Lieleg, Oliver
Abstract:
Gaining control over the delivery of therapeutics to a specific disease site is still very challenging. However, especially when cytotoxic drugs such as chemotherapeutics are used, the importance of a control mechanism that can differentiate “sick” target cells from the surrounding healthy tissue is pivotal. Here, we designed a nanoparticle-based drug delivery process, which releases an active agent only in the presence of a specific trigger DNA sequence. With this strategy, we are able to initi...     »
Keywords:
antibiotics doxorubicin drug delivery nanoparticles DNA nanotechnology
Dewey Decimal Classification:
500 Naturwissenschaften
Journal title:
ACS Nano
Year:
2020
Journal volume:
15
Journal issue:
2
Pages contribution:
2350-2362
Covered by:
Web of Science
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1021/acsnano.0c04035
WWW:
https://pubs.acs.org/doi/abs/10.1021/acsnano.0c04035
Publisher:
American Chemical Society (ACS)
E-ISSN:
1936-08511936-086X
Date of publication:
07.08.2020
TUM Institution:
Professur für Biomechanik
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