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Titel:

Repulsive Backbone–Backbone Interactions Modulate Access to Specific and Unspecific Binding Sites on Surface-Bound Mucins

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Lutz, Theresa M.; Marczynski, Matthias; Grill, Maximilian J.; Wall, Wolfgang A.; Lieleg, Oliver
Abstract:
Mucin glycoproteins are the matrix-forming key components of mucus, the innate protective barrier protecting us from pathogenic attack. However, this barrier is constantly challenged by mucin-degrading enzymes, which tend to target anionic glycan chains such as sulfate groups and sialic acid residues. Here, we demonstrate that the efficiency of both unspecific and specific binding of small molecules to mucins is reduced when sulfate groups are enzymatically removed from mucins; this is unexpect...     »
Stichworte:
Anions, Peptides and proteins, Carbohydrates, Genetics, Molecules
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Langmuir
Jahr:
2020
Band / Volume:
36
Heft / Issue:
43
Seitenangaben Beitrag:
12973-12982
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1021/acs.langmuir.0c02256
WWW:
https://pubs.acs.org/doi/10.1021/acs.langmuir.0c02256
Verlag / Institution:
American Chemical Society (ACS)
E-ISSN:
0743-74631520-5827
Publikationsdatum:
22.10.2020
TUM Einrichtung:
Fachgebiet für Biomechanik
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