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Title:

Engineering an orchestrated release avalanche from hydrogels using DNA-nanotechnology

Document type:
Zeitschriftenaufsatz
Author(s):
Kimna, Ceren; Lieleg, Oliver
Abstract:
Most medical therapies require repeated, sequential administration of therapeutic agents in well-defined intervals and over extended time windows. Typically, the patient is in charge of applying the individual drug doses, and insufficient patient compliance reduces the efficiency of the treatment. Therefore, the development of a smart delivery mechanism releasing therapeutic agents in a pre-defined, time-controlled fashion would be beneficial for many medical treatments. Here, we present a DNA-m...     »
Keywords:
DNA linker, Drug delivery, Nanoparticles, Sequential release
Journal title:
Journal of Controlled Release
Year:
2019
Journal volume:
304
Pages contribution:
19-28
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.jconrel.2019.04.028
WWW:
https://www.sciencedirect.com/science/article/pii/S0168365919302287
Publisher:
Elsevier BV
E-ISSN:
0168-3659
Date of publication:
01.06.2019
TUM Institution:
Fachgebiet für Biomechanik
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