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Titel:

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wittlich, Michaela; Dudek, Michael; Böttcher, Jan P; Schanz, Oliver; Hegenbarth, Silke; Bopp, Tobias; Schmitt, Edgar; Kurts, Christian; Garbers, Christoph; Rose John, Stefan; Knolle, Percy A; Wohlleber, Dirk
Abstract:
Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to the formation of memory T cells that is preceded by transient Granzyme B (GzmB) expression. Here we provide evidence for a so far unrecognized CD4 T helper cell function in LSEC-induced CD8 T cell activation.Naïve CD8 T cells and differentiated T helper 1 (T1)...     »
Zeitschriftentitel:
J Hepatol
Jahr:
2017
Band / Volume:
66
Heft / Issue:
5
Seitenangaben Beitrag:
978-986
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jhep.2016.12.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28025060
Print-ISSN:
0168-8278
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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