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Titel:

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination.

Dokumenttyp:
Journal Article; 8
Autor(en):
Heine, Annkristin; Flores, Chrystel; Gevensleben, Heidrun; Diehl, Linda; Heikenwälder, Mathias; Ringelhan, Marc; Janssen, Klaus-Peter; Nitsche, Ulrich; Garbi, Natalio; Brossart, Peter; Knolle, Percy A; Kurts, Christian; Höchst, Bastian
Abstract:
Tumor immune escape is a critical problem which frequently accounts for the failure of therapeutic tumor vaccines. Among the most potent suppressors of tumor immunity are myeloid derived suppressor cells (MDSCs). MDSCs can be targeted by all-trans-retinoic-acid (atRA), which reduced their numbers and increased response rates in several vaccination studies. However, not much is known about the optimal administration interval between atRA and the vaccine as well as about its mode of action. Here w...     »
Zeitschriftentitel:
Oncoimmunology
Jahr:
2017
Band / Volume:
6
Heft / Issue:
8
Seitenangaben Beitrag:
e1338995
Sprache:
eng
Volltext / DOI:
doi:10.1080/2162402X.2017.1338995
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28920004
Print-ISSN:
2162-4011
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Roman Herzog Comprehensive Cancer Center
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