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Titel:

Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.

Dokumenttyp:
Journal Article
Autor(en):
Volckmar, Julia; Gereke, Marcus; Ebensen, Thomas; Riese, Peggy; Philipsen, Lars; Lienenklaus, Stefan; Wohlleber, Dirk; Klopfleisch, Robert; Stegemann-Koniszewski, Sabine; Müller, Andreas J; Gruber, Achim D; Knolle, Percy; Guzman, Carlos A; Bruder, Dunja
Abstract:
Hepatotropic viruses such as hepatitis C virus cause life-threatening chronic liver infections in millions of people worldwide. Targeted in vivo antigen-delivery to cross-presenting dendritic cells (DCs) has proven to be extraordinarily efficient in stimulating antigen-specific T cell responses. To determine whether this approach would as well be suitable to induce local antiviral effector T cells in the liver we compared different vaccine formulations based on either the targeting of DEC-205 or...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2017
Band / Volume:
7
Seitenangaben Beitrag:
43985
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep43985
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28266658
Print-ISSN:
2045-2322
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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