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Title:

Transient binding promotes molecule penetration into mucin hydrogels by enhancing molecular partitioning

Document type:
Zeitschriftenaufsatz
Author(s):
Marczynski, Matthias; Käsdorf, Benjamin T.; Altaner, Bernhard; Wenzler, Andreas; Gerland, Ulrich; Lieleg, Oliver
Abstract:
Here, we present a microfluidics chip platform which allows for studying the charge-dependent transport of molecules across the interface of acidic mucin gels. With this setup, we demonstrate a selective accumulation of molecules at the liquid/gel interface of mucin hydrogels that occurs as a function of the molecule charge: this phenomenon is strongly pronounced for cationic molecules, weakly pronounced for anionic molecules and absent for neutral molecules. We suggest that molecular transport...     »
Dewey Decimal Classification:
570 Biowissenschaften, Biologie
Journal title:
Biomaterials Science
Year:
2018
Journal volume:
6
Journal issue:
12
Pages contribution:
3373-3387
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1039/c8bm00664d
WWW:
https://pubs.rsc.org/en/Content/ArticleLanding/2018/BM/C8BM00664D#!divAbstract
Publisher:
Royal Society of Chemistry (RSC)
E-ISSN:
2047-48302047-4849
Date of publication:
01.01.2018
TUM Institution:
Fachgebiet für Biomechanik, MW
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