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Title:

Type and capacity of glucose transport influences succinate yield in two-stage cultivations

Document type:
Zeitschriftenaufsatz
Author(s):
L. Kyselova; D. Kreitmayer; A. Kremling and K. Bettenbrock
Abstract:
Background Glucose is the main carbon source of E. coli and a typical substrate in production processes. The main glucose uptake system is the glucose specific phosphotransferase system (Glc-PTS). The PTS couples glucose uptake with its phosphorylation. This is achieved by the concomitant conversion of phosphoenolpyruvate (PEP) to pyruvate. The Glc-PTS is hence unfavorable for the production of succinate as this product is derived from PEP. Results We studied, in a systematic manner, the ef...     »
Keywords:
Succinate production; Two stage cultivations; Glucose transport; Flux balance analysis; APT; Pck
Journal title:
Open Access Articles and Journals in Engineering
Year:
2018
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1186/s12934-018-0980-1
WWW:
https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-018-0980-1
Date of publication:
28.08.2018
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