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Title:

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.

Document type:
Journal Article; Article
Author(s):
Bauernfeind, Franz; Niepmann, Sven; Knolle, Percy A; Hornung, Veit
Abstract:
Accumulating evidence suggests that the activation of the innate branch of the immune system plays a pivotal role in the induction and perpetuation of metabolic and aging-related diseases. In this context, the NLRP3 inflammasome pathway has been identified as an important driver of sterile inflammatory processes. De novo protein synthesis of NLRP3 induced by signals such as TLR ligands or TNF is a prerequisite for sustained NLRP3 mediated caspase-1 cleavage and inflammasome activation. Here, we...     »
Journal title abbreviation:
J Immunol
Year:
2016
Journal volume:
197
Journal issue:
7
Pages contribution:
2900-8
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1501336
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27566828
Print-ISSN:
0022-1767
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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