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Title:

Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.

Document type:
Journal Article; Article
Author(s):
Schuette, Verena; Embgenbroich, Maria; Ulas, Thomas; Welz, Meike; Schulte-Schrepping, Jonas; Draffehn, Astrid M; Quast, Thomas; Koch, Katharina; Nehring, Melanie; König, Jessica; Zweynert, Annegret; Harms, Frederike L; Steiner, Nancy; Limmer, Andreas; Förster, Irmgard; Berberich-Siebelt, Friederike; Knolle, Percy A; Wohlleber, Dirk; Kolanus, Waldemar; Beyer, Marc; Schultze, Joachim L; Burgdorf, Sven
Abstract:
The mannose receptor (MR) is an endocytic receptor involved in serum homeostasis and antigen presentation. Here, we identify the MR as a direct regulator of CD8(+) T-cell activity. We demonstrate that MR expression on dendritic cells (DCs) impaired T-cell cytotoxicity in vitro and in vivo. This regulatory effect of the MR was mediated by a direct interaction with CD45 on the T cell, inhibiting its phosphatase activity, which resulted in up-regulation of cytotoxic T-lymphocyte-associated Protein...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2016
Journal volume:
113
Journal issue:
38
Pages contribution:
10649-54
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1605885113
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27601670
Print-ISSN:
0027-8424
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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