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Title:

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rietscher, René; Schröder, Matthias; Janke, Julia; Czaplewska, Justyna; Gottschaldt, Michael; Scherließ, Regina; Hanefeld, Andrea; Schubert, Ulrich S; Schneider, Marc; Knolle, Percy A; Lehr, Claus-Michael
Abstract:
Here, we evaluate the use of hydrophilic PEG-b-PAGE-b-PLGA (PPP) for the preparation of antigen loaded nanoparticles (NPs) as a platform for prophylactic vaccination. To investigate the suitability of PPP-NPs for antigen delivery, we used the double emulsion evaporation technique to prepare NPs of different sizes, antigen-loading efficiencies and -release kinetics for the model antigen Ovalbumin (OVA). Prior to applying the PPP-NPs in biological in vitro or in vivo models, all materials were tes...     »
Journal title abbreviation:
Eur J Pharm Biopharm
Year:
2016
Journal volume:
102
Pages contribution:
20-31
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ejpb.2016.02.014
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26940132
Print-ISSN:
0939-6411
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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