User: Guest  Login
Title:

Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Siegmund, S V; Wojtalla, A; Schlosser, M; Schildberg, F A; Knolle, P A; Nüsing, R M; Zimmer, A; Strassburg, C P; Singer, M V
Abstract:
The endogenous cannabinoid 2-arachidonoyl glycerol (2-AG) is an anti-fibrotic lipid mediator that induces apoptosis in hepatic stellate cells (HSCs), but not in hepatocytes. However, the exact molecular mechanisms of this selective induction of HSC death are still unresolved. Interestingly, the inducible isoform of cyclooxygenase, COX-2, can metabolize 2-AG to pro-apoptotic prostaglandin glycerol esters (PG-GEs). We analyzed the roles of COX-2 and endocannabinoid-derived PG-GEs in the differenti...     »
Journal title abbreviation:
Biochem Biophys Res Commun
Year:
2016
Journal volume:
470
Journal issue:
3
Pages contribution:
678-84
Language:
eng
Fulltext / DOI:
doi:10.1016/j.bbrc.2016.01.083
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26801558
Print-ISSN:
0006-291X
TUM Institution:
Roman Herzog Comprehensive Cancer Center
 BibTeX