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Titel:

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.

Dokumenttyp:
Journal Article; Article
Autor(en):
Bauernfeind, Franz; Niepmann, Sven; Knolle, Percy A; Hornung, Veit
Abstract:
Accumulating evidence suggests that the activation of the innate branch of the immune system plays a pivotal role in the induction and perpetuation of metabolic and aging-related diseases. In this context, the NLRP3 inflammasome pathway has been identified as an important driver of sterile inflammatory processes. De novo protein synthesis of NLRP3 induced by signals such as TLR ligands or TNF is a prerequisite for sustained NLRP3 mediated caspase-1 cleavage and inflammasome activation. Here, we...     »
Zeitschriftentitel:
J Immunol
Jahr:
2016
Band / Volume:
197
Heft / Issue:
7
Seitenangaben Beitrag:
2900-8
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.1501336
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27566828
Print-ISSN:
0022-1767
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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