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Titel:

Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.

Dokumenttyp:
Journal Article; 16
Autor(en):
Hagemeyer, Nora; Kierdorf, Katrin; Frenzel, Kathrin; Xue, Jia; Ringelhan, Marc; Abdullah, Zeinab; Godin, Isabelle; Wieghofer, Peter; Costa Jordão, Marta Joana; Ulas, Thomas; Yorgancioglu, Gülden; Rosenbauer, Frank; Knolle, Percy A; Heikenwälder, Mathias; Schultze, Joachim L; Prinz, Marco
Abstract:
Recent studies have shown that tissue macrophages (M?) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize tissues before birth. Further studies have proposed that developmentally distinct tissue M? can be identified based on the differential expression of F4/80 and CD11b, but whether a characteristic transcriptional profile exists is largely unknown. Here, we took advantage of an inducible fate-mapping system that facilitated the identification of CD45(+)c-kit(-)C...     »
Zeitschriftentitel:
EMBO J
Jahr:
2016
Band / Volume:
35
Heft / Issue:
16
Seitenangaben Beitrag:
1730-44
Sprache:
eng
Volltext / DOI:
doi:10.15252/embj.201693801
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27412700
Print-ISSN:
0261-4189
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Roman Herzog Comprehensive Cancer Center
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