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Titel:

Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Siegmund, S V; Wojtalla, A; Schlosser, M; Schildberg, F A; Knolle, P A; Nüsing, R M; Zimmer, A; Strassburg, C P; Singer, M V
Abstract:
The endogenous cannabinoid 2-arachidonoyl glycerol (2-AG) is an anti-fibrotic lipid mediator that induces apoptosis in hepatic stellate cells (HSCs), but not in hepatocytes. However, the exact molecular mechanisms of this selective induction of HSC death are still unresolved. Interestingly, the inducible isoform of cyclooxygenase, COX-2, can metabolize 2-AG to pro-apoptotic prostaglandin glycerol esters (PG-GEs). We analyzed the roles of COX-2 and endocannabinoid-derived PG-GEs in the differenti...     »
Zeitschriftentitel:
Biochem Biophys Res Commun
Jahr:
2016
Band / Volume:
470
Heft / Issue:
3
Seitenangaben Beitrag:
678-84
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.bbrc.2016.01.083
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26801558
Print-ISSN:
0006-291X
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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