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Titel:

Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem Cell Pool.

Dokumenttyp:
Journal Article; Article
Autor(en):
Ruf, Franziska; Schreck, Christina; Wagner, Alina; Grziwok, Sandra; Pagel, Charlotta; Romero, Sandra; Kieslinger, Matthias; Shimono, Akihiko; Peschel, Christian; Götze, Katharina S; Istvánffy, Rouzanna; Oostendorp, Robert A J
Abstract:
Sfrp2 is overexpressed in stromal cells which maintain hematopoietic stem cells (HSCs) during in vitro culture. We here showed, that coculture of hematopoetic cells with stromal cells with reduced expression of Sfrp2 increases the number lineage-negative Kit(+) Sca-1(+) (LSK) and progenitor cells in vitro. The LSK cells from these cocultures showed activation of canonical Wnt signaling, higher levels of Ki-67, BrdU incorporation, and the number of ?H2A.X positive foci. Total repopulating activit...     »
Zeitschriftentitel:
Stem Cells
Jahr:
2016
Band / Volume:
34
Heft / Issue:
9
Seitenangaben Beitrag:
2381-92
Sprache:
eng
Volltext / DOI:
doi:10.1002/stem.2416
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27299503
Print-ISSN:
1066-5099
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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