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Title:

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ritter, M; Gross, O; Kays, S; Ruland, J; Nimmerjahn, F; Saijo, S; Tschopp, J; Layland, LE; Prazeres da Costa, C
Abstract:
The propensity of helminths, such as schistosomes, to immunomodulate the host's immune system is an essential aspect of their survival. Previous research has demonstrated how soluble schistosomal egg antigens (SEA) dampen TLR-signaling during innate immune responses. We show here that the suppressive effect by SEA on TLR signaling is simultaneously coupled to the activation of the Nlrp3 (NLR family, pyrin domain containing 3) inflammasome and thus IL-1? production. Therefore, the responsible pro...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2010
Journal volume:
107
Journal issue:
47
Pages contribution:
20459-64
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1010337107
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21059925
Print-ISSN:
0027-8424
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Roman Herzog Comprehensive Cancer Center
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