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Titel:

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ritter, M; Gross, O; Kays, S; Ruland, J; Nimmerjahn, F; Saijo, S; Tschopp, J; Layland, LE; Prazeres da Costa, C
Abstract:
The propensity of helminths, such as schistosomes, to immunomodulate the host's immune system is an essential aspect of their survival. Previous research has demonstrated how soluble schistosomal egg antigens (SEA) dampen TLR-signaling during innate immune responses. We show here that the suppressive effect by SEA on TLR signaling is simultaneously coupled to the activation of the Nlrp3 (NLR family, pyrin domain containing 3) inflammasome and thus IL-1? production. Therefore, the responsible pro...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2010
Band / Volume:
107
Heft / Issue:
47
Seitenangaben Beitrag:
20459-64
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1010337107
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21059925
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Roman Herzog Comprehensive Cancer Center
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