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- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Fischer, T; Schobel, HP; Frank, H; Andreae, M; Schneider, KT; Heusser, K
- Titel:
- Pregnancy-induced sympathetic overactivity: a precursor of preeclampsia.
- Abstract:
- BACKGROUND: Preeclampsia has been shown to constitute a state of sympathetic overactivity. However, it remains unclear if the sympathetic activity precedes preeclampsia or represents only a secondary phenomenon. To further investigate this issue, we performed a prospective study in pregnant women considered to be at increased risk for preeclampsia owing to preeclampsia during a preceding pregnancy. MATERIALS AND METHODS: Twenty-two women with a history of preeclampsia were longitudinally studied on three occasions: twice during pregnancy (M1: 22 +/- 4, M2: 33 +/- 5 weeks) and once postpartum (M3: 26 +/- 6 weeks postpartum). We measured muscle sympathetic nerve activity (MSNA), forearm blood flow, and blood pressure at rest and during reactive hyperaemia after forearm occlusion. RESULTS: At M1 and M2, none of the subjects was hypertensive, however, muscle sympathetic nerve activity levels were significantly augmented, compared with their postpartum values (M1: 21 +/- 9, M2: 29 +/- 14, M3: 9 +/- 5 bursts min(-1); P < 0.05). Forearm vascular resistance did not significantly change from M1 through M3 (M1: 16 +/- 9, M2: 15 +/- 7, M3: 16 +/- 7 U; P = NS). Gestational muscle sympathetic nerve activity values did not differ significantly among the subjects with subsequent preeclampsia compared with those who remained normotensive [with preeclampsia (n = 6): M1: 21 +/- 5, M2: 27 +/- 6, M3: 7 +/- 4 bursts min(-1); without preeclampsia (n = 16): M1: 21 +/- 11, M2: 30 +/- 16, M3: 9 +/- 6 bursts min(-1); P = NS]. CONCLUSION: Invariably, all women at risk for preeclampisa showed a pregnancy-induced increase in MSNA (pregnancy-induced sympathetic overactivity, PISO), which normalized after delivery. Most importantly, PISO is not necessarily associated with peripheral vasoconstriction and hypertension. Furthermore, only a subset of patients developed preeclampsia later on. Therefore, we hypothesize that PISO constitutes a precursor of preeclampsia which is physiologically compensated for by vasodilating mechanisms, leading to preeclampsia only when they fail.
- Zeitschriftentitel:
- Eur J Clin Invest
- Jahr:
- 2004
- Band / Volume:
- 34
- Heft / Issue:
- 6
- Seitenangaben Beitrag:
- 443-8
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1111/j.1365-2362.2004.01350.x
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/15200497
- Print-ISSN:
- 0014-2972
- TUM Einrichtung:
- Fachgebiet Nephrologie (Prof. Heemann); Fachgebiet Perinatalmedizin und Perinatalphysiologie (Prof. Schneider)
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