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Title:

Inactivated Orf virus (Parapoxvirus ovis) elicits antifibrotic activity in models of liver fibrosis.

Document type:
Journal Article; Article
Author(s):
Nowatzky, Janina; Knorr, Andreas; Hirth-Dietrich, Claudia; Siegling, Angela; Volk, Hans-Dieter; Limmer, Andreas; Knolle, Percy; Weber, Olaf
Abstract:
Inactivated Orf virus (ORFV, Parapoxvirus ovis) demonstrates strong antiviral activity in animal models including a human hepatitis B virus (HBV)-transgenic mouse. In addition, expression of interferon (IFN)-? and interleukin-10 (IL-10) was induced after administration of inactivated ORFV in these mice. IFN-? and IL-10 are known to elicit antifibrotic activity. We therefore aimed to study antifibrotic activity of inactivated ORFV in models of liver fibrosis.We characterized ORFV-induced hepatic...     »
Journal title abbreviation:
Hepatol Res
Year:
2013
Journal volume:
43
Journal issue:
5
Pages contribution:
535-46
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1872-034X.2012.01086.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22971208
Print-ISSN:
1386-6346
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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