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Title:

The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Niño-Castro, Andrea; Abdullah, Zeinab; Popov, Alexey; Thabet, Yasser; Beyer, Marc; Knolle, Percy; Domann, Eugen; Chakraborty, Trinad; Schmidt, Susanne V; Schultze, Joachim L
Abstract:
Induction of indoleamine 2,3-dioxygenase (IDO1) is an established cellular response to infection with numerous pathogens. Several mechanisms, such as IDO1-mediated tryptophan (Trp) depletion, but also accumulation of Trp catabolites, have been associated with the antimicrobial effects of IDO(+) cells. Recent findings of IDO1 as an immunoinhibitory and signaling molecule extended these previous observations. Using infection of professional phagocytes with Listeria monocytogenes (L.m.) as a model,...     »
Journal title abbreviation:
Innate Immun
Year:
2014
Journal volume:
20
Journal issue:
4
Pages contribution:
401-11
Language:
eng
Fulltext / DOI:
doi:10.1177/1753425913496442
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23940074
Print-ISSN:
1753-4259
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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