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Titel:

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

Dokumenttyp:
Journal Article; Article
Autor(en):
De Nardo, Dominic; Labzin, Larisa I; Kono, Hajime; Seki, Reiko; Schmidt, Susanne V; Beyer, Marc; Xu, Dakang; Zimmer, Sebastian; Lahrmann, Catharina; Schildberg, Frank A; Vogelhuber, Johanna; Kraut, Michael; Ulas, Thomas; Kerksiek, Anja; Krebs, Wolfgang; Bode, Niklas; Grebe, Alena; Fitzgerald, Michael L; Hernandez, Nicholas J; Williams, Bryan R G; Knolle, Percy; Kneilling, Manfred; Röcken, Martin; Lütjohann, Dieter; Wright, Samuel D; Schultze, Joachim L; Latz, Eicke
Abstract:
High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory diseases. The molecular mechanisms of how HDL can modulate inflammation, particularly in immune cells such as macrophages, remain poorly understood. Here we identify the transcriptional regulator ATF3, as an HDL-inducible target gene in macrophages that d...     »
Zeitschriftentitel:
Nat Immunol
Jahr:
2014
Band / Volume:
15
Heft / Issue:
2
Seitenangaben Beitrag:
152-60
Sprache:
eng
Volltext / DOI:
doi:10.1038/ni.2784
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24317040
Print-ISSN:
1529-2908
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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