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Titel:

The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Niño-Castro, Andrea; Abdullah, Zeinab; Popov, Alexey; Thabet, Yasser; Beyer, Marc; Knolle, Percy; Domann, Eugen; Chakraborty, Trinad; Schmidt, Susanne V; Schultze, Joachim L
Abstract:
Induction of indoleamine 2,3-dioxygenase (IDO1) is an established cellular response to infection with numerous pathogens. Several mechanisms, such as IDO1-mediated tryptophan (Trp) depletion, but also accumulation of Trp catabolites, have been associated with the antimicrobial effects of IDO(+) cells. Recent findings of IDO1 as an immunoinhibitory and signaling molecule extended these previous observations. Using infection of professional phagocytes with Listeria monocytogenes (L.m.) as a model,...     »
Zeitschriftentitel:
Innate Immun
Jahr:
2014
Band / Volume:
20
Heft / Issue:
4
Seitenangaben Beitrag:
401-11
Sprache:
eng
Volltext / DOI:
doi:10.1177/1753425913496442
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23940074
Print-ISSN:
1753-4259
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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