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Title:

Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kaczmarek, Julita; Homsi, Yahya; van Üüm, Jan; Metzger, Christina; Knolle, Percy A; Kolanus, Waldemar; Lang, Thorsten; Diehl, Linda
Abstract:
The initiation of adaptive immunity requires cell-to-cell contact between T cells and antigen-presenting cells. Together with immediate TCR signal transduction, the formation of an immune synapse (IS) is one of the earliest events detected during T cell activation. Here, we show that interaction of liver sinusoidal endothelial cells (LSEC) with naive CD8 T cells, which induces CD8 T cells without immediate effector function, is characterized by a multi-focal type IS. The co-inhibitory molecule B...     »
Journal title abbreviation:
PLoS ONE
Year:
2014
Journal volume:
9
Journal issue:
6
Pages contribution:
e99574
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0099574
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24924593
Print-ISSN:
1932-6203
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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