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Title:

Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Schiwon, Marzena; Weisheit, Christina; Franken, Lars; Gutweiler, Sebastian; Dixit, Akanksha; Meyer-Schwesinger, Catherine; Pohl, Judith-Mira; Maurice, Nicholas J; Thiebes, Stephanie; Lorenz, Kristina; Quast, Thomas; Fuhrmann, Martin; Baumgarten, Georg; Lohse, Martin J; Opdenakker, Ghislain; Bernhagen, Jürgen; Bucala, Rick; Panzer, Ulf; Kolanus, Waldemar; Gröne, Hermann-Josef; Garbi, Natalio; Kastenmüller, Wolfgang; Knolle, Percy A; Kurts, Christian; Engel, Daniel R
Abstract:
The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C(-) macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C(+) macrophages. Such Ly6C(+) macrophages played a previously undescribed helper role: once recruited...     »
Journal title abbreviation:
Cell
Year:
2014
Journal volume:
156
Journal issue:
3
Pages contribution:
456-68
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2014.01.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24485454
Print-ISSN:
0092-8674
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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