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Title:

IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Böttcher, Jan P; Schanz, Oliver; Garbers, Christoph; Zaremba, Anne; Hegenbarth, Silke; Kurts, Christian; Beyer, Marc; Schultze, Joachim L; Kastenmüller, Wolfgang; Rose-John, Stefan; Knolle, Percy A
Abstract:
Immune control of infections with viruses or intracellular bacteria relies on cytotoxic CD8(+) T cells that use granzyme B (GzmB) for elimination of infected cells. During inflammation, mature antigen-presenting dendritic cells instruct naive T cells within lymphoid organs to develop into effector T cells. Here, we report a mechanistically distinct and more rapid process of effector T cell development occurring within 18 hr. Such rapid acquisition of effector T cell function occurred through cro...     »
Journal title abbreviation:
Cell Rep
Year:
2014
Journal volume:
8
Journal issue:
5
Pages contribution:
1318-27
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2014.07.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25199826
Print-ISSN:
2211-1247
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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