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Title:

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

Document type:
Journal Article; Article
Author(s):
De Nardo, Dominic; Labzin, Larisa I; Kono, Hajime; Seki, Reiko; Schmidt, Susanne V; Beyer, Marc; Xu, Dakang; Zimmer, Sebastian; Lahrmann, Catharina; Schildberg, Frank A; Vogelhuber, Johanna; Kraut, Michael; Ulas, Thomas; Kerksiek, Anja; Krebs, Wolfgang; Bode, Niklas; Grebe, Alena; Fitzgerald, Michael L; Hernandez, Nicholas J; Williams, Bryan R G; Knolle, Percy; Kneilling, Manfred; Röcken, Martin; Lütjohann, Dieter; Wright, Samuel D; Schultze, Joachim L; Latz, Eicke
Abstract:
High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory diseases. The molecular mechanisms of how HDL can modulate inflammation, particularly in immune cells such as macrophages, remain poorly understood. Here we identify the transcriptional regulator ATF3, as an HDL-inducible target gene in macrophages that d...     »
Journal title abbreviation:
Nat Immunol
Year:
2014
Journal volume:
15
Journal issue:
2
Pages contribution:
152-60
Language:
eng
Fulltext / DOI:
doi:10.1038/ni.2784
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24317040
Print-ISSN:
1529-2908
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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