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Titel:

Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kaczmarek, Julita; Homsi, Yahya; van Üüm, Jan; Metzger, Christina; Knolle, Percy A; Kolanus, Waldemar; Lang, Thorsten; Diehl, Linda
Abstract:
The initiation of adaptive immunity requires cell-to-cell contact between T cells and antigen-presenting cells. Together with immediate TCR signal transduction, the formation of an immune synapse (IS) is one of the earliest events detected during T cell activation. Here, we show that interaction of liver sinusoidal endothelial cells (LSEC) with naive CD8 T cells, which induces CD8 T cells without immediate effector function, is characterized by a multi-focal type IS. The co-inhibitory molecule B...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2014
Band / Volume:
9
Heft / Issue:
6
Seitenangaben Beitrag:
e99574
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0099574
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24924593
Print-ISSN:
1932-6203
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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