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Title:

Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Paulsen, Daniela; Urban, Andreas; Knorr, Andreas; Hirth-Dietrich, Claudia; Siegling, Angela; Volk, Hans-Dieter; Mercer, Andrew A; Limmer, Andreas; Schumak, Beatrix; Knolle, Percy; Ruebsamen-Schaeff, Helga; Weber, Olaf
Abstract:
Inactivated orf virus (iORFV), strain D1701, is a potent immune modulator in various animal species. We recently demonstrated that iORFV induces strong antiviral activity in animal models of acute and chronic viral infections. In addition, we found D1701-mediated antifibrotic effects in different rat models of liver fibrosis. In the present study, we compare iORFV derived from two different strains of ORFV, D1701 and NZ2, respectively, with respect to their antifibrotic potential as well as thei...     »
Journal title abbreviation:
PLoS ONE
Year:
2013
Journal volume:
8
Journal issue:
9
Pages contribution:
e74605
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0074605
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24066148
Print-ISSN:
1932-6203
TUM Institution:
Roman Herzog Comprehensive Cancer Center
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